Systemic lupus erythematosus-associated diffuse alveolar hemorrhage: A case report and review of the literature

Luisa Morales-Nebreda, Omolola Alakija, Keith T. Ferguson, Benjamin D. Singer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Systemic lupus erythematosus is associated with numerous pleuropulmonary complications. Although uncommon, diffuse alveolar hemorrhage (DAH) represents a life-threatening cause of acute respiratory failure among patients with lupus. Here, we present a 24-year-old woman with a history of lupus who developed hemoptysis and respiratory failure associated with diffuse radiographic infiltrates and anemia. Bronchoscopy confirmed DAH. She was managed with supportive care, plasmapheresis, and immunosuppressive pharmacotherapy, leading to sustained resolution of her pulmonary hemorrhage and respiratory failure. We review the available literature on the pathophysiology and management of lupus-associated DAH, which centers on supportive care, reversal of coagulopathy, and immunosuppressive measures.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalClinical Pulmonary Medicine
Volume25
Issue number5
DOIs
StatePublished - Sep 1 2018

Keywords

  • antiphospholipid syndrome
  • capillaritis
  • diffuse alveolar hemorrhage
  • respiratory failure
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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