Systemic lupus erythematosus glomerulonephritis in children

E. H. Garin, S. T. Shulman, W. H. Donnelly, G. A. Richard

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This paper reviews the four types of systemic lupus erythematosus (SLE) glomerulonephritis in children and presents the clinical and renal histologic findings. A therapeutic program based upon the hypothesis that the nephritis of SLE is the result of the glomerular deposition of pathogenic dsDNA-anti-dsDNA immune complexes is outlined. The effectiveness of therapy in suppressing disease activity is best estimated by serial determinations of serum complement components, particularly C3, and secondarily by monitoring serum levels of antibody to native DNA.

Original languageEnglish (US)
Pages (from-to)351-367
Number of pages17
JournalPaediatrician
Volume10
Issue number5-6
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Garin, E. H., Shulman, S. T., Donnelly, W. H., & Richard, G. A. (1981). Systemic lupus erythematosus glomerulonephritis in children. Paediatrician, 10(5-6), 351-367.