Systemic mycosis due to trichosporon cutaneum a report of two additional cases

Harry L. Evans*, Morris Kletzel, Ronald D. Lawson, Lawrence S. Frankel, Roy L. Hopfer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Two additional cases of systemic mycosis due to Trichosporon cutaneum are reported and are compared with the previously published case of Rivera and Cangir. Both patients (a four‐year‐old male and a 57‐year‐old female) had acute leukemia for which they were receiving chemotherapy, and both presented with fever that was unresponsive to conventional antibiotics. Both had positive blood cultures for Trichosporon cutaneum. The disease was further documented in the four‐year‐old male by renal biopsy and by bone marrow culture; he was treated with apparent success with amphotericin B. However, the 57‐year‐old female died shortly after the beginning of similar treatment, and autopsy demonstrated involvement of the left kidney, spleen, bone marrow, and liver. The organism in both these cases, as well as the case of Rivera and Cangir, exhibited both hyphal and yeastlike forms in tissue sections. We believe that the therapeutic success in the case of the four‐year‐old male was primarily related to his remission from leukemia.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalCancer
Volume45
Issue number2
DOIs
StatePublished - Jan 15 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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