Systemic sclerosis: A prototypic multisystem fibrotic disorder

John Varga*, David Abraham

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

965 Scopus citations


A unique feature of systemic sclerosis (SSc) that distinguishes it from other fibrotic disorders is that autoimmunity and vasculopathy characteristically precede fibrosis. Moreover, fibrosis in SSc is not restricted to a single organ, but rather affects many organs and accounts for much of the morbidity and mortality associated with this disease. Although immunomodulatory drugs have been used extensively in the treatment of SSc, no therapy to date has been able to reverse or slow the progression of tissue fibrosis or substantially modify the natural progression of the disease. In this Review, we highlight recent studies that shed light on the cellular and molecular mechanisms underlying the fibrotic process in SSc and that identify cellular processes and intra- and extracellular proteins as potential novel targets for therapy in this prototypic multisystemic fibrotic disease.

Original languageEnglish (US)
Pages (from-to)557-567
Number of pages11
JournalJournal of Clinical Investigation
Issue number3
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Medicine(all)


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