Systemic sclerosis: An update

John Varga*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Systemic sclerosis (SSc) is a complex and heterogeneous chronic illness characterized by substantial patient to patient variability in clinical manifestations, internal organ involvement, and outcome. Genetic factors contribute to disease susceptibility, but environmental influences also play a significant role. The pathogenesis of SSc encompasses vascular, immunological, and fibrotic processes, which contribute to clinical manifestations and morbidity and must be addressed in the treatment plan. Although vascular interventions appear to reduce the frequency and severity of complications, such as scleroderma renal crisis and pulmonary hypertension, current therapies generally target the immune component of SSc in a non-selective fashion and have largely failed as diseases-modifying interventions. Newer insights into the mechanisms underlying autoimmunity, vascular injury and destruction, and particularly tissue fibrosis provide novel potential targets for therapy. Transforming growth factor-β is a ubiquitous cytokine that appears to contribute to fibroblast activation, collagen overproduction, and pathological tissue fibrosis. Neutralizing antibodies and small molecules that block TGF-β activation or function are effective in shutting down TGF-β signaling and selectively inhibit the progression of fibrosis and may be entering clinical trials for the treatment of SSc.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalBulletin of the NYU Hospital for Joint Diseases
Issue number3
StatePublished - 2008

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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