Systolic/diastolic ratio correlates with end diastolic pressures in pediatric patients with single right ventricles

Clifford L. Cua*, Melissa Moore-Clingenpeel, Nazia Husain, Ralf Holzer, John P. Cheatham, Janaki Gokhale

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Increased ventricular end-diastolic pressure (VEDP) is a known risk factor for morbidity and mortality in patients with single right ventricle (RV) physiology. Previous studies have shown mixed results correlating echocardiographic measurements with catheter-derived VEDP in this population. Goal of this study was to evaluate if echocardiographic systolic/diastolic ratio (S/D) correlated with VEDP. Methods: Patients with single RV physiology who underwent simultaneous echocardiography and catheterization were evaluated. Systolic and diastolic durations were measured using tricuspid inflow durations from Doppler analysis to calculate the S/D ratio. VEDP was obtained from the catheterization report. Results: Twenty-seven studies were performed on patients with single RV physiology. Median age at time of catheterization was 11.4 months (range, 0-132 months). Mean VEDP was 9.9 ± 4.5 mm Hg. S/D ratio was 1.8 ± 0.5. S/D ratio significantly correlated with VEDP (r = 0.63, P <.01). Optimum value of S/D ratio for discriminating between patients with high (>10 mm Hg) vs low EDP was found to be 1.9. High S/D ratio had an area under the curve of 0.82 (0.65, 1.0), with 75% sensitivity and 89% specificity for predicting elevated VEDP. Conclusion: In patients with single RV physiology, S/D significantly correlated with VEDP. S/D ratio is a simple technique that may be useful in both estimating and discriminating between high and low VEDP in this complex patient population.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalCongenital Heart Disease
Issue number4
StatePublished - 2019


  • catheterization
  • echocardiography
  • hypoplastic left heart syndrome
  • single right ventricle
  • systolic/diastolic ratio

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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