TY - JOUR
T1 - T-cell-receptor β- and I-Aβ-chain genes of normal SWR mice are linked with the development of lupus nephritis in NZB x SWR crosses
AU - Ghatak, S.
AU - Sainis, K.
AU - Owen, F. L.
AU - Datta, S. K.
PY - 1987
Y1 - 1987
N2 - The incidence of nephritis in autoimmune New Zealand Black (NZB) mice is low, but when they are crossed with normal SWR mice, almost 100% of the female F1 hybrids (SNF1) develop lethal glomerulonephritis. To define the contribution of the normal SWR strain to the development of nephritis, we analyzed the association of the I-Aβ-chain gene of Ia-encoding region, the T-cell-receptor β (TcRβ)-chain gene, and immunoglobulin heavy-chain allotype (IgH) with the development of lupus nephritis in 165 NZB x SWR crosses. We found that genes linked to the TcR and Ir gene loci of the normal SWR mice interacted with NZB-derived genes, leading to the development of accelerated and severe nephritis in the NZB x SWR crosses.
AB - The incidence of nephritis in autoimmune New Zealand Black (NZB) mice is low, but when they are crossed with normal SWR mice, almost 100% of the female F1 hybrids (SNF1) develop lethal glomerulonephritis. To define the contribution of the normal SWR strain to the development of nephritis, we analyzed the association of the I-Aβ-chain gene of Ia-encoding region, the T-cell-receptor β (TcRβ)-chain gene, and immunoglobulin heavy-chain allotype (IgH) with the development of lupus nephritis in 165 NZB x SWR crosses. We found that genes linked to the TcR and Ir gene loci of the normal SWR mice interacted with NZB-derived genes, leading to the development of accelerated and severe nephritis in the NZB x SWR crosses.
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U2 - 10.1073/pnas.84.19.6850
DO - 10.1073/pnas.84.19.6850
M3 - Article
C2 - 3477811
AN - SCOPUS:0023567295
SN - 0027-8424
VL - 84
SP - 6850
EP - 6853
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 19
ER -