T cell regulation of antibody responses: An I-A-specific, autoreactive T cell collaborates with antigen-specific helper T cells to promote IgG responses

C. Clayberger, R. H. DeKruyff, H. Cantor

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In earlier studies we showed that hapten-specific inducer T cell clones specifically induce B cells from immunized donors to secrete IgM antibodies. However, IgG responses were not observed, suggesting that an additional signal(s) was required. In this report, we show that an autoreactive T cell clone produces a factor(s) that collaborates with antigen-specific inducer T cells to promote specific IgG responses. This factor is not restricted by antigen or MHC determinants and promotes IgG production both in vivo and in vitro. These findings suggest that autoreactive cells may play an important role in the regulation of isotype expression.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalJournal of Immunology
Volume134
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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