T-cell response dynamics in animal models of multiple sclerosis: Implications for immunotherapies

Bettina Schreiner; Samantha L. Bailey; Stephen D. Miller

doi:10.1586/1744666X.3.1.57

T-cell response dynamics in animal models of multiple sclerosis: Implications for immunotherapies

Bettina Schreiner^*, Samantha L. Bailey, Stephen D. Miller

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Multiple sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system with a complex immune nature and varied clinical presentation. Current therapies for MS are limited by toxicity and efficacy, so interest has now turned to specifically modulating autoreactive T-cell responses. Murine MS models, such as experimental autoimmune encephalomyelitis (EAE), have proved invaluable for understanding the immune components of MS and for designing and testing potential immunotherapies. Here, we review the current knowledge of the mechanisms of induction and progression of EAE and MS and the immunotherapies that have resulted from studies of the EAE model.

Original language	English (US)
Pages (from-to)	57-72
Number of pages	16
Journal	Expert Review of Clinical Immunology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1586/1744666X.3.1.57
State	Published - Jan 2007

Funding

This work was supported in part by research grants from the National Institutes of Health, the National Multiple Sclerosis Society, and the Myelin Repair Foundation. SLB was supported by NMSS Postdoctoral Fellowship Grant FG 1563 A-1, BS by a fellowship from the Deutsche Forschungsgemeinschaft.

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1586/1744666X.3.1.57

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title = "T-cell response dynamics in animal models of multiple sclerosis: Implications for immunotherapies",

abstract = "Multiple sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system with a complex immune nature and varied clinical presentation. Current therapies for MS are limited by toxicity and efficacy, so interest has now turned to specifically modulating autoreactive T-cell responses. Murine MS models, such as experimental autoimmune encephalomyelitis (EAE), have proved invaluable for understanding the immune components of MS and for designing and testing potential immunotherapies. Here, we review the current knowledge of the mechanisms of induction and progression of EAE and MS and the immunotherapies that have resulted from studies of the EAE model.",

author = "Bettina Schreiner and Bailey, {Samantha L.} and Miller, {Stephen D.}",

note = "Funding Information: This work was supported in part by research grants from the National Institutes of Health, the National Multiple Sclerosis Society, and the Myelin Repair Foundation. SLB was supported by NMSS Postdoctoral Fellowship Grant FG 1563 A-1, BS by a fellowship from the Deutsche Forschungsgemeinschaft.",

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AU - Miller, Stephen D.

N1 - Funding Information: This work was supported in part by research grants from the National Institutes of Health, the National Multiple Sclerosis Society, and the Myelin Repair Foundation. SLB was supported by NMSS Postdoctoral Fellowship Grant FG 1563 A-1, BS by a fellowship from the Deutsche Forschungsgemeinschaft.

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N2 - Multiple sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system with a complex immune nature and varied clinical presentation. Current therapies for MS are limited by toxicity and efficacy, so interest has now turned to specifically modulating autoreactive T-cell responses. Murine MS models, such as experimental autoimmune encephalomyelitis (EAE), have proved invaluable for understanding the immune components of MS and for designing and testing potential immunotherapies. Here, we review the current knowledge of the mechanisms of induction and progression of EAE and MS and the immunotherapies that have resulted from studies of the EAE model.

AB - Multiple sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system with a complex immune nature and varied clinical presentation. Current therapies for MS are limited by toxicity and efficacy, so interest has now turned to specifically modulating autoreactive T-cell responses. Murine MS models, such as experimental autoimmune encephalomyelitis (EAE), have proved invaluable for understanding the immune components of MS and for designing and testing potential immunotherapies. Here, we review the current knowledge of the mechanisms of induction and progression of EAE and MS and the immunotherapies that have resulted from studies of the EAE model.

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T-cell response dynamics in animal models of multiple sclerosis: Implications for immunotherapies

Abstract

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ASJC Scopus subject areas

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