T-Lymphocyte-antigen interactions in transplant rejection

Alan M. Krensky*, Arthur Weiss, Gerald Crabtree, Mark M. Davis, Peter Parham

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

242 Scopus citations


THE replacement of malfunctioning tissues and organs has long been a clinical objective in medicine. Modern transplantation has been made possible by improved clinical care, a better understanding of immunogenetics, cross-matching of antibodies, and the development of several nonspecific immunosuppressive agents, including corticosteroids, azathioprine, antilymphocyte serum, cyclosporine, and monoclonal antibodies. The combination of HLA matching and immunosuppression has greatly improved both graft and patient survival, but several complications persist: infection, hypertension, drug toxicity, recurrence of disease, and psychosocial problems. Identifying more specific modes of immunosuppression therefore remains a challenge for clinical medicine. A thorough understanding of the cellular, biochemical, and.

Original languageEnglish (US)
Pages (from-to)510-517
Number of pages8
JournalNew England Journal of Medicine
Issue number8
StatePublished - Feb 22 1990

ASJC Scopus subject areas

  • General Medicine


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