T lymphocyte-endothelial cell interactions

Jaehyuk Choi*, David R. Enis, Kian Peng Koh, Stephen L. Shiao, Jordan S. Pober

*Corresponding author for this work

Research output: Contribution to journalReview article

149 Citations (Scopus)

Abstract

Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.

Original languageEnglish (US)
Pages (from-to)683-709
Number of pages27
JournalAnnual Review of Immunology
Volume22
DOIs
StatePublished - Jun 7 2004

Fingerprint

Cell Communication
Endothelial Cells
T-Lymphocytes
Antigen Presentation
HLA Antigens
Cardiovascular System
Blood Vessels
Immune System
Maintenance
Antigens
Peptides

Keywords

  • Antigen presentation
  • Cytokines
  • Endothelial activation
  • Endothelial dysfunction
  • Vascular biology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Choi, Jaehyuk ; Enis, David R. ; Koh, Kian Peng ; Shiao, Stephen L. ; Pober, Jordan S. / T lymphocyte-endothelial cell interactions. In: Annual Review of Immunology. 2004 ; Vol. 22. pp. 683-709.
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T lymphocyte-endothelial cell interactions. / Choi, Jaehyuk; Enis, David R.; Koh, Kian Peng; Shiao, Stephen L.; Pober, Jordan S.

In: Annual Review of Immunology, Vol. 22, 07.06.2004, p. 683-709.

Research output: Contribution to journalReview article

TY - JOUR

T1 - T lymphocyte-endothelial cell interactions

AU - Choi, Jaehyuk

AU - Enis, David R.

AU - Koh, Kian Peng

AU - Shiao, Stephen L.

AU - Pober, Jordan S.

PY - 2004/6/7

Y1 - 2004/6/7

N2 - Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.

AB - Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.

KW - Antigen presentation

KW - Cytokines

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KW - Vascular biology

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