Abstract
Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-709 |
| Number of pages | 27 |
| Journal | Annual Review of Immunology |
| Volume | 22 |
| DOIs | |
| State | Published - Jun 7 2004 |
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Keywords
- Antigen presentation
- Cytokines
- Endothelial activation
- Endothelial dysfunction
- Vascular biology
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
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T lymphocyte-endothelial cell interactions. / Choi, Jaehyuk; Enis, David R.; Koh, Kian Peng; Shiao, Stephen L.; Pober, Jordan S.
In: Annual Review of Immunology, Vol. 22, 07.06.2004, p. 683-709.Research output: Contribution to journal › Review article
TY - JOUR
T1 - T lymphocyte-endothelial cell interactions
AU - Choi, Jaehyuk
AU - Enis, David R.
AU - Koh, Kian Peng
AU - Shiao, Stephen L.
AU - Pober, Jordan S.
PY - 2004/6/7
Y1 - 2004/6/7
N2 - Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.
AB - Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.
KW - Antigen presentation
KW - Cytokines
KW - Endothelial activation
KW - Endothelial dysfunction
KW - Vascular biology
UR - http://www.scopus.com/inward/record.url?scp=2542440670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542440670&partnerID=8YFLogxK
U2 - 10.1146/annurev.immunol.22.012703.104639
DO - 10.1146/annurev.immunol.22.012703.104639
M3 - Review article
C2 - 15032593
AN - SCOPUS:2542440670
VL - 22
SP - 683
EP - 709
JO - Annual Review of Immunology
JF - Annual Review of Immunology
SN - 0732-0582
ER -