T lymphocyte-endothelial cell interactions

Jaehyuk Choi*, David R. Enis, Kian Peng Koh, Stephen L. Shiao, Jordan S. Pober

*Corresponding author for this work

Research output: Contribution to journalReview article

150 Scopus citations

Abstract

Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependant signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance of permselectivity, recruitment of inflammatory leukocytes, and antigen presentation leading to activation of T cells. T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems.

Original languageEnglish (US)
Pages (from-to)683-709
Number of pages27
JournalAnnual Review of Immunology
Volume22
DOIs
StatePublished - Jun 7 2004

    Fingerprint

Keywords

  • Antigen presentation
  • Cytokines
  • Endothelial activation
  • Endothelial dysfunction
  • Vascular biology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this