T Rosette assay In vitro correlate of cellular immunity

William J. Catalona*, Claude Potvin, John L. Tarpley, Paul B. Chretien

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The T rosette assay, based on the capacity of thymus-derived lymphocytes (mediators of tumor-inhibiting immunity) to bind sheep erythrocytes in vitro, was used to quantitate percentages of T rosette-forming lymphocytes in the peripheral blood of 38 patients with urologic cancer. Results obtained using the T rosette assay yielded statistically significant direct correlations with those obtained using two other assays which have been widely employed to monitor cellular immunity: elicitation of delayed hypersensitivity to DNCB (dinitrochlorobenzene) and the proliferative response of lymphocytes to PHA (phytohemagglutinin). The findings suggest the T rosette assay provides a meaningful in vitro correlate of cellular immunity.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalUrology
Volume4
Issue number1
DOIs
StatePublished - Jul 1974

ASJC Scopus subject areas

  • Urology

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