T-SPOT.TB Reactivity in Southern African Children with and Without in Utero Human Immunodeficiency Virus Exposure

Saori C. Iwase; Paul T. Edlefsen; Lynnette Bhebhe; Kesego Motsumi; Sikhulile Moyo; Anna Ursula Happel; Danica Shao; Nicholas Mmasa; Sara Schenkel; Melanie A. Gasper; Melanie Dubois; Megan A. Files; Chetan Seshadri; Fergal Duffy; John Aitchison; Mihai G. Netea; Jennifer Jao; Donald W. Cameron; Clive M. Gray; Heather B. Jaspan; Kathleen M. Powis

doi:10.1093/cid/ciad356

T-SPOT.TB Reactivity in Southern African Children with and Without in Utero Human Immunodeficiency Virus Exposure

Saori C. Iwase^*, Paul T. Edlefsen, Lynnette Bhebhe, Kesego Motsumi, Sikhulile Moyo, Anna Ursula Happel, Danica Shao, Nicholas Mmasa, Sara Schenkel, Melanie A. Gasper, Melanie Dubois, Megan A. Files, Chetan Seshadri, Fergal Duffy, John Aitchison, Mihai G. Netea, Jennifer Jao, Donald W. Cameron, Clive M. Gray, Heather B. JaspanKathleen M. Powis

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-GuCrossed D sign.

Original language	English (US)
Pages (from-to)	1133-1136
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	77
Issue number	8
DOIs	https://doi.org/10.1093/cid/ciad356
State	Published - Oct 15 2023

Funding

Financial support. This work was supported by the National Institute of Allergies and Infectious Disease (NIAID) (grant number R01AI142670 awarded to K. M. P.). The Tshilo Dikotla study was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (grant number R01DK109881 awarded to J. J.). The InFANT study was supported in part by the Global Health Research Initiative (GHRI), a research funding partnership composed of the Canadian Institutes of Health Research, the Canadian International Development Agency, and the International Development Research Centre (grant number THA-118568 awarded to H. B. J. and C. M G.), as well as the NIAID (grant number R01AI120714-01A1 awarded to H. B. J.) and National Institute of Child Health and Human Development (NICHD) (grant number R21HD083344 awarded to H. B. J. and C. M. G.). M. D. was supported by NIAID (grant number T32AI007433). S. C. I. was funded by Yoshida Scholarship Foundation.

Keywords

HIV exposure
Southern Africa
T-SPOT.TB
TB infection
infants

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cid/ciad356

Cite this

Iwase, S. C., Edlefsen, P. T., Bhebhe, L., Motsumi, K., Moyo, S., Happel, A. U., Shao, D., Mmasa, N., Schenkel, S., Gasper, M. A., Dubois, M., Files, M. A., Seshadri, C., Duffy, F., Aitchison, J., Netea, M. G., Jao, J., Cameron, D. W., Gray, C. M., ... Powis, K. M. (2023). T-SPOT.TB Reactivity in Southern African Children with and Without in Utero Human Immunodeficiency Virus Exposure. Clinical Infectious Diseases, 77(8), 1133-1136. https://doi.org/10.1093/cid/ciad356

@article{4527980e40514a3dbaab8e76d440fc95,

title = "T-SPOT.TB Reactivity in Southern African Children with and Without in Utero Human Immunodeficiency Virus Exposure",

abstract = "Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-GuCrossed D sign.",

keywords = "HIV exposure, Southern Africa, T-SPOT.TB, TB infection, infants",

author = "Iwase, {Saori C.} and Edlefsen, {Paul T.} and Lynnette Bhebhe and Kesego Motsumi and Sikhulile Moyo and Happel, {Anna Ursula} and Danica Shao and Nicholas Mmasa and Sara Schenkel and Gasper, {Melanie A.} and Melanie Dubois and Files, {Megan A.} and Chetan Seshadri and Fergal Duffy and John Aitchison and Netea, {Mihai G.} and Jennifer Jao and Cameron, {Donald W.} and Gray, {Clive M.} and Jaspan, {Heather B.} and Powis, {Kathleen M.}",

note = "Publisher Copyright: {\textcopyright}rin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status. ",

year = "2023",

month = oct,

day = "15",

doi = "10.1093/cid/ciad356",

language = "English (US)",

volume = "77",

pages = "1133--1136",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "8",

}

Iwase, SC, Edlefsen, PT, Bhebhe, L, Motsumi, K, Moyo, S, Happel, AU, Shao, D, Mmasa, N, Schenkel, S, Gasper, MA, Dubois, M, Files, MA, Seshadri, C, Duffy, F, Aitchison, J, Netea, MG, Jao, J, Cameron, DW, Gray, CM, Jaspan, HB & Powis, KM 2023, 'T-SPOT.TB Reactivity in Southern African Children with and Without in Utero Human Immunodeficiency Virus Exposure', Clinical Infectious Diseases, vol. 77, no. 8, pp. 1133-1136. https://doi.org/10.1093/cid/ciad356

TY - JOUR

T1 - T-SPOT.TB Reactivity in Southern African Children with and Without in Utero Human Immunodeficiency Virus Exposure

AU - Iwase, Saori C.

AU - Edlefsen, Paul T.

AU - Bhebhe, Lynnette

AU - Motsumi, Kesego

AU - Moyo, Sikhulile

AU - Happel, Anna Ursula

AU - Shao, Danica

AU - Mmasa, Nicholas

AU - Schenkel, Sara

AU - Gasper, Melanie A.

AU - Dubois, Melanie

AU - Files, Megan A.

AU - Seshadri, Chetan

AU - Duffy, Fergal

AU - Aitchison, John

AU - Netea, Mihai G.

AU - Jao, Jennifer

AU - Cameron, Donald W.

AU - Gray, Clive M.

AU - Jaspan, Heather B.

AU - Powis, Kathleen M.

N1 - Publisher Copyright: ©rin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

PY - 2023/10/15

Y1 - 2023/10/15

N2 - Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-GuCrossed D sign.

AB - Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-GuCrossed D sign.

KW - HIV exposure

KW - Southern Africa

KW - T-SPOT.TB

KW - TB infection

KW - infants

UR - http://www.scopus.com/inward/record.url?scp=85174752398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85174752398&partnerID=8YFLogxK

U2 - 10.1093/cid/ciad356

DO - 10.1093/cid/ciad356

M3 - Article

C2 - 37293702

AN - SCOPUS:85174752398

SN - 1058-4838

VL - 77

SP - 1133

EP - 1136

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 8

ER -

T-SPOT.TB Reactivity in Southern African Children with and Without in Utero Human Immunodeficiency Virus Exposure

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this