T4 urothelial carcinoma in undiagnosed closed bladder exstrophy in a postmenopausal female

Brian J. McArdle*, Patricia Vidal, Sarah P. Psutka, Courtney M.P. Hollowell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

It is rare to see an adult presenting with exstrophy of the bladder. Malignant conversion in exstrophy occurs in 4%, with adenocarcinoma as the most common histopathology. We report the first case of metastatic high grade urothelial carcinoma with squamous and sarcomatoid differentiation arising from undiagnosed, closed bladder exstrophy in a female at advanced age with associated bilateral deep vein thrombosis and clot retention. The patient developed clinical progression of disease despite neoadjuvant gemcitabine-cisplatin and salvage (or palliative) radiotherapy. To the best of our knowledge, this is the first reported case of a primary urothelial malignancy in occult bladder exstrophy.

Original languageEnglish (US)
Pages (from-to)9214-9216
Number of pages3
JournalCanadian Journal of Urology
Volume25
Issue number1
StatePublished - Feb 1 2018

Keywords

  • Closed bladder exstrophy
  • Congenital anomaly
  • Unreconstructed bladder exstrophy
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Urology

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