Tailored nanoscale contrast agents for magnetic resonance imaging

Alex J. Barker*, Brant Cage, Stephen Russek, Ruchira Garg, Robin Shandas, Conrad R. Stoldt

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Two potential molecular imaging vectors are investigated for material properties and magnetic resonance imaging (MRI) contrast improvement. Monodisperse magnetite (Fe3O4) nanocrystals ranging in size from 7 to 22 nm are solvothermally synthesized by thermolysis of Fe(III) acetylacetonate (Fe(AcAc)3) both with and without the use of heptanoic acid (HA) as a capping ligand. For the resulting Fe3O 4 nanocrystals, X-Ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM (HRTEM), and superconducting quantum interference device magnetometry (SQUID) is used to identify the average particle size, monodispersity, crystal symmetry, and magnetic properties of the ensembles as a function of time. The characterization study indicates that the HA synthesis route at 3 hours produced nanoparticles with the greatest magnetic anisotropy (15.8 × 104" J/m3"). The feasibility of Fe 8 single molecule magnets (SMMs) as a potential MRI contrast agent is also examined. SQUID magnetization measurements are used to determine anisotropy and saturation of the potential agents. The effectiveness of the Fe3O4 nanocrystals and Fe8 as potential MRI molecular probes is evaluated by MRI contrast improvement using 1.5 mL phantoms dispersed in de-ionized water. Results indicate that the magnetically optimized Fe3O4 nanocrystals and Fe8 SMMs hold promise for use as contrast agents based on the reported MRI images and solution phase T1/T2 shortening.

Original languageEnglish (US)
Title of host publicationElectronic and Photonic Packaging, Integration and Packaging of Micro/Nano/Electronic Systems - 2005
Pages581-590
Number of pages10
Volume5
DOIs
StatePublished - Dec 1 2005
Event2005 ASME International Mechanical Engineering Congress and Exposition, IMECE - Orlando, FL, United States
Duration: Nov 5 2005Nov 11 2005

Other

Other2005 ASME International Mechanical Engineering Congress and Exposition, IMECE
CountryUnited States
CityOrlando, FL
Period11/5/0511/11/05

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering

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