Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and efflux

Andrea J. Luthi, Heng Zhang, Dongwoo Kim, David A. Giljohann, Chad A. Mirkin, C. Shad Thaxton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Figure Persented: Gold nanoparticles (Au NPs) were employed as templates to synthesize spherical, high-density lipoprotein (HDL) biomimics (HDL Au NPs) of different sizes and surface chemistries. The effect of size and surface chemistry on the cholesterol binding properties and the ability of the HDL Au NPs to efflux cholesterol from macrophage cells were measured. Results demonstrate that Au NPs may be utilized as templates to generate nanostructures with different physical characteristics that mimic natural HDL. Furthermore, the properties of the HDL Au NPs may be tailored to modulate the ability to bind cholesterol in solution and efflux cholesterol from macrophages. From the conjugates tested, the optimum size and surface chemistry for preparing functional Au NP-templated HDL biomimics were identified.

Original languageEnglish (US)
Pages (from-to)276-285
Number of pages10
JournalACS nano
Volume6
Issue number1
DOIs
StatePublished - Jan 24 2012

Keywords

  • atherosclerosis
  • biomimic
  • cholesterol efflux
  • gold
  • high-density lipoprotein
  • nanoparticle

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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