Abstract
Figure Persented: Gold nanoparticles (Au NPs) were employed as templates to synthesize spherical, high-density lipoprotein (HDL) biomimics (HDL Au NPs) of different sizes and surface chemistries. The effect of size and surface chemistry on the cholesterol binding properties and the ability of the HDL Au NPs to efflux cholesterol from macrophage cells were measured. Results demonstrate that Au NPs may be utilized as templates to generate nanostructures with different physical characteristics that mimic natural HDL. Furthermore, the properties of the HDL Au NPs may be tailored to modulate the ability to bind cholesterol in solution and efflux cholesterol from macrophages. From the conjugates tested, the optimum size and surface chemistry for preparing functional Au NP-templated HDL biomimics were identified.
Original language | English (US) |
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Pages (from-to) | 276-285 |
Number of pages | 10 |
Journal | ACS nano |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Jan 24 2012 |
Keywords
- atherosclerosis
- biomimic
- cholesterol efflux
- gold
- high-density lipoprotein
- nanoparticle
ASJC Scopus subject areas
- General Materials Science
- General Engineering
- General Physics and Astronomy