Talc Retinopathy in Primates: A Model of Ischemic Retinopathy: III. An Electron Microscopic Study

Norio Kaga, Mark O M Tso, Lee M. Jampol

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Electron microscopic study of experimental talc retinopathy provides an opportunity to study the basic cytologic response of retinal and choroidal vessels to small, relatively inert emboli. Occlusion of the retinal and choroidal capillaries resulted primarily from the cellular reaction to, rather than directly from, the emboli. Mitotic figures in pericytes were observed. Even though we failed to produce retinal neovascularization (as is sometimes seen in human talc retinopathy) in this experimental model, our observations suggest that proliferation of pericytes may be an initial step in the process of retinal neovascularization.

Original languageEnglish (US)
Pages (from-to)1649-1657
Number of pages9
JournalArchives of ophthalmology
Volume100
Issue number10
DOIs
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Ophthalmology

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