@article{aee584a0354a44b9b2a158bc029bdaba,
title = "TALEN-mediated editing of the mouse y chromosome",
abstract = "The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes - Sry and Uty. TALEN-mediated gene editing is a useful tool for dissecting the biology of the Y chromosome.",
author = "Haoyi Wang and Hu, {Yueh Chiang} and Styliani Markoulaki and Welstead, {G. Grant} and Cheng, {Albert W.} and Shivalila, {Chikdu S.} and Tatyana Pyntikova and Dadon, {Daniel B.} and Voytas, {Daniel F.} and Bogdanove, {Adam J.} and Page, {David C.} and Rudolf Jaenisch",
note = "Funding Information: We thank K. Ganz and R. Flannery for support with animal care and experiments. We thank Jaenisch and Page laboratory members for helpful discussions on the manuscript. A.W.C. is supported by a Croucher scholarship. D.C.P. and Y.-C.H. were supported by Howard Hughes Medical Institute. R.J., H.W., S.M., G.G.W., C.S.S. and A.W.C. were supported by US National Institutes of Health grants R37-HD045022 and R01-CA084198. T.P. was supported by US National Institutes of Health grant R01-HG000257.",
year = "2013",
month = jun,
doi = "10.1038/nbt.2595",
language = "English (US)",
volume = "31",
pages = "530--532",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",
number = "6",
}