TY - JOUR
T1 - Target-specific expression of presynaptic mossy fiber plasticity
AU - Maccaferri, Gianmaria
AU - Tóth, Katalin
AU - McBain, Chris J.
PY - 1998/2/27
Y1 - 1998/2/27
N2 - Mossy fiber synaptic transmission at hippocampal CA3 pyramidal cells and interneurons was compared in rat brain slices to determine whether mossy terminals are functionally equivalent. Tetanic stimulation of mossy fibers induce long-term potentiation in pyramidal neurons but was either without effect or it induced depression at synapses onto interneurons. Unlike transmission onto pyramidal neurons, transmission onto interneurons was not potentiated after adenosine 3',5'-monophosphate (cAMP) activation. Furthermore, metabotropic glutamate receptor depression of transmission onto interneurons did not involve cAMP-dependent pathways. Thus, synaptic terminals arising from a common afferent pathway do not function as a single compartment but are specialized, depending on their postsynaptic target.
AB - Mossy fiber synaptic transmission at hippocampal CA3 pyramidal cells and interneurons was compared in rat brain slices to determine whether mossy terminals are functionally equivalent. Tetanic stimulation of mossy fibers induce long-term potentiation in pyramidal neurons but was either without effect or it induced depression at synapses onto interneurons. Unlike transmission onto pyramidal neurons, transmission onto interneurons was not potentiated after adenosine 3',5'-monophosphate (cAMP) activation. Furthermore, metabotropic glutamate receptor depression of transmission onto interneurons did not involve cAMP-dependent pathways. Thus, synaptic terminals arising from a common afferent pathway do not function as a single compartment but are specialized, depending on their postsynaptic target.
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U2 - 10.1126/science.279.5355.1368
DO - 10.1126/science.279.5355.1368
M3 - Article
C2 - 9478900
AN - SCOPUS:0032570569
VL - 279
SP - 1368
EP - 1370
JO - Science
JF - Science
SN - 0036-8075
IS - 5355
ER -