Targetable pathogenic mechanisms in nasal polyposis

Alexander L. Schneider, Robert P. Schleimer, Bruce K. Tan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) represents a challenging disease entity with significant rates of recurrence following appropriate medical and surgical therapy. Recent approval of targeted biologics in CRSwNP compels deeper understanding of underlying disease pathophysiology. Both of the approved biologics for CRSwNP modulate the type 2 inflammatory pathway, and the majority of drugs in the clinical trials pathway are similarly targeted. However, there remain multiple other pathogenic mechanisms relevant to CRSwNP for which targeted therapeutics already exist in other inflammatory diseases that have not been studied directly. In this article we summarize pathogenic mechanisms of interest in CRSwNP and discuss the results of ongoing clinical studies of targeted therapeutics in CRSwNP and other related human inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)1220-1234
Number of pages15
JournalInternational Forum of Allergy and Rhinology
Volume11
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • biologic therapies
  • chronic rhinosinusitis with nasal polyps
  • type 2 inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

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