Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

Luke F. Vistain; Matthew W. Rotz; Richa Rathore; Adam T. Preslar; Thomas J. Meade

doi:10.1039/c5cc06565h

Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

Luke F. Vistain, Matthew W. Rotz, Richa Rathore, Adam T. Preslar, Thomas J. Meade^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Detection of protein expression by MRI requires a high payload of Gd(iii) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(iii) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

Original language	English (US)
Pages (from-to)	160-163
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	1
DOIs	https://doi.org/10.1039/c5cc06565h
State	Published - 2016

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

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title = "Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging",

abstract = "Detection of protein expression by MRI requires a high payload of Gd(iii) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(iii) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.",

author = "Vistain, {Luke F.} and Rotz, {Matthew W.} and Richa Rathore and Preslar, {Adam T.} and Meade, {Thomas J.}",

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AU - Vistain, Luke F.

AU - Rotz, Matthew W.

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AU - Preslar, Adam T.

AU - Meade, Thomas J.

PY - 2016

Y1 - 2016

N2 - Detection of protein expression by MRI requires a high payload of Gd(iii) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(iii) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

AB - Detection of protein expression by MRI requires a high payload of Gd(iii) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(iii) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

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Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

Abstract

ASJC Scopus subject areas

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