Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging

Luke F. Vistain, Matthew W. Rotz, Richa Rathore, Adam T. Preslar, Thomas J. Meade*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Detection of protein expression by MRI requires a high payload of Gd(iii) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(iii) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalChemical Communications
Volume52
Issue number1
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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