Targeted gene repair and its application to neurodegenerative disorders

Hetal Parekh-Olmedo; Dimitri Krainc; Eric B. Kmiec

doi:10.1016/S0896-6273(02)00594-9

Targeted gene repair and its application to neurodegenerative disorders

Hetal Parekh-Olmedo, Dimitri Krainc, Eric B. Kmiec^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Synthetic DNA oligonucleotides can direct the exchange of single nucleotides within coding regions of mammalian genes by hybridizing to their complementary sequence in the chromosome and creating a recombination joint structure with a single mismatched base pair. Inherent DNA repair processes recognize the mismatch and resolve it using the DNA sequence of the oligonucleotide vector as the template. This gene surgery approach can be used to repair mutations or to disrupt tri-nucleotide repeats in dysfunctional genes responsible for neurological disorders.

Original language	English (US)
Pages (from-to)	495-498
Number of pages	4
Journal	Neuron
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/S0896-6273(02)00594-9
State	Published - Feb 14 2002

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/S0896-6273(02)00594-9

Cite this

@article{04ca7d8dbd784cb09413becc7988952e,

title = "Targeted gene repair and its application to neurodegenerative disorders",

abstract = "Synthetic DNA oligonucleotides can direct the exchange of single nucleotides within coding regions of mammalian genes by hybridizing to their complementary sequence in the chromosome and creating a recombination joint structure with a single mismatched base pair. Inherent DNA repair processes recognize the mismatch and resolve it using the DNA sequence of the oligonucleotide vector as the template. This gene surgery approach can be used to repair mutations or to disrupt tri-nucleotide repeats in dysfunctional genes responsible for neurological disorders.",

author = "Hetal Parekh-Olmedo and Dimitri Krainc and Kmiec, {Eric B.}",

year = "2002",

month = feb,

day = "14",

doi = "10.1016/S0896-6273(02)00594-9",

language = "English (US)",

volume = "33",

pages = "495--498",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Targeted gene repair and its application to neurodegenerative disorders

AU - Parekh-Olmedo, Hetal

AU - Krainc, Dimitri

AU - Kmiec, Eric B.

PY - 2002/2/14

Y1 - 2002/2/14

N2 - Synthetic DNA oligonucleotides can direct the exchange of single nucleotides within coding regions of mammalian genes by hybridizing to their complementary sequence in the chromosome and creating a recombination joint structure with a single mismatched base pair. Inherent DNA repair processes recognize the mismatch and resolve it using the DNA sequence of the oligonucleotide vector as the template. This gene surgery approach can be used to repair mutations or to disrupt tri-nucleotide repeats in dysfunctional genes responsible for neurological disorders.

AB - Synthetic DNA oligonucleotides can direct the exchange of single nucleotides within coding regions of mammalian genes by hybridizing to their complementary sequence in the chromosome and creating a recombination joint structure with a single mismatched base pair. Inherent DNA repair processes recognize the mismatch and resolve it using the DNA sequence of the oligonucleotide vector as the template. This gene surgery approach can be used to repair mutations or to disrupt tri-nucleotide repeats in dysfunctional genes responsible for neurological disorders.

UR - http://www.scopus.com/inward/record.url?scp=0037075199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037075199&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(02)00594-9

DO - 10.1016/S0896-6273(02)00594-9

M3 - Review article

C2 - 11856524

AN - SCOPUS:0037075199

SN - 0896-6273

VL - 33

SP - 495

EP - 498

JO - Neuron

JF - Neuron

IS - 4

ER -

Targeted gene repair and its application to neurodegenerative disorders

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this