Targeted Muscle Reinnervation as a Strategy for Neuroma Prevention

Jason H. Ko, Peter S. Kim, Douglas G. Smith

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


When a peripheral nerve is transected, a bulbous swelling, or neuroma, will develop at the severed end of the nerve (Figure 4.1). Neuromas consist of disorganized, chaotic axons encased in significant scar and fibrous tissue. They are frequently sensitive to pressure and other forms of mechanical irritation, causing a focal pain that is often difficult to treat. By providing a distal muscle target for the proximal transected axons to grow into, targeted muscle reinnervation (TMR) may represent a novel technique for the prevention and treatment of neuromas. In this chapter, we will discuss the pathophysiology.

Original languageEnglish (US)
Title of host publicationTargeted Muscle Reinnervation
Subtitle of host publicationA Neural Interface for Artificial Limbs
PublisherCRC Press
Number of pages22
ISBN (Electronic)9781439860816
ISBN (Print)9781138198647
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)


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