Targeted nanoagents for the detection of cancers

Jason R. McCarthy*, Jayeeta Bhaumik, Mark R. Karver, S. Sibel Erdem, Ralph Weissleder

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


Nanotechnology has enabled a renaissance in the diagnosis of cancers. This is due, in part to the ability to develop agents bearing multiple functionalities, including those utilized for targeting, imaging, and therapy, allowing for the tailoring of the properties of the nanomaterials. Whereas many nanomaterials exhibit localization to diseased tissues via intrinsic targeting, the addition of targeting ligands, such as antibodies, peptides, aptamers, and small molecules, facilitates far more sensitive cancer detection. As such, this review focuses upon some of the most poignant examples of the utility of affinity ligand targeted nanoagents in the detection of cancer.

Original languageEnglish (US)
Pages (from-to)511-528
Number of pages18
JournalMolecular oncology
Issue number6
StatePublished - Dec 2010


  • Affinity ligands
  • Imaging
  • Nanomedicine

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Oncology
  • Cancer Research


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