Targeted therapies in bone sarcomas: Current approach and future directions

Jessica Lee Yarber, Mark Agulnik

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Introduction: Bone sarcomas are rare malignancies and once advanced, there is limited response to current chemotherapeutic regimens. Targeted therapies could have substantial impact on these diseases. Areas covered: Specific molecular targets of bone sarcomas are reviewed along with the various targeted therapies that have potential to change the outcome of these chemotherapy resistant diseases. Expert opinion: There are promising pathways identified that targeted inhibitors could provide better treatment options for metastatic bone sarcomas. There is a strong need for continued Phase II and III clinical trials investigating these molecularly targeted therapies.

Original languageEnglish (US)
Pages (from-to)973-979
Number of pages7
JournalExpert Opinion on Investigational Drugs
Volume20
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • bone sarcoma
  • molecular targets
  • review
  • targeted therapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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