Targeting allergen to FcγRI: A strategy to treat allergic disease?

Kathryn E. Hulse, Judith A. Woodfolk

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Purpose of review: Targeting allergens to surface receptors on antigen presenting cells may provide a therapeutic strategy for allergic disease. This article discusses the immunomodulatory capacity of a molecule (H22-Fel d 1), which targets the major cat allergen, Fel d 1, to the high affinity IgG receptor, FcγRI, on human dendritic cells. Recent findings: The fusion protein, H22-Fel d 1, induced a semi-mature phenotype in dendritic cells characterized by production of inflammatory cytokines with no change in surface markers, suggesting tolerogenic capacity. At the T-cell level, H22-Fel d 1 stimulated increased proliferation coupled with amplification of T cells expressing IL-5 and IL-10. Further analysis revealed induction of diverse T cell subtypes characteristic of Th0, regulatory Th1 and regulatory Th2 cells. Notably, this effect was restricted to T cells isolated from cat-allergic patients. Despite the increase in IL-5-expressing T cells, responses induced by H22-Fel d 1 appeared to be regulated by IL-10. Comparison with nonreceptor-targeted allergens from cat and house dust mite confirmed that qualitative T-cell changes induced by H22-Fel d 1 were unique. Summary: H22-Fel d 1 induces a novel variation of the Th2 response, which incorporates elements of a protective T-cell response. Exploiting FcγRI-mediated pathways for allergen delivery may offer a new approach for treatment.

Original languageEnglish (US)
Pages (from-to)547-552
Number of pages6
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2008

Keywords

  • CD4+ T cells
  • Dendritic cell-based vaccines
  • Fcγ receptors
  • FcεRI
  • Fel d 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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