Targeting AMPK in the treatment of malignancies

Eliza Vakana, Jessica K. Altman, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

The AMPK pathway is a metabolic stress-related and energy censor pathway which plays important regulatory roles in normal and malignant cells. This cellular cascade controls generation of signals for initiation of mRNA translation via the mTOR pathway and exhibits regulatory roles on the initiation of autophagy. AMPK activators have been shown to suppress mTOR activity and to negatively control malignant transformation and cell proliferation of diverse malignant cell types. Such properties of AMPK inducers have generated substantial interest for the use of AMPK targeting compounds as antineoplastic agents and have provoked extensive research efforts to better define and classify the mechanisms controlling AMPK activity and its functional consequences in malignant cells.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
JournalJournal of Cellular Biochemistry
Volume113
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • AMPK
  • Cancer
  • mTOR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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