Abstract
Cai et al. report that MORRBID/Morrbid expression is aberrantly increased in human AML patients and mouse models for CMML, MPN, and AML. Genetic loss of Morrbid makes leukemic cells vulnerable to apoptosis and mitigates the progression of myeloid neoplasms. High expression of MORRBID in humans is associated with poor survival of AML patients.
Original language | English (US) |
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Article number | 107816 |
Journal | Cell reports |
Volume | 31 |
Issue number | 12 |
DOIs | |
State | Published - Jun 23 2020 |
Funding
We thank our colleagues for technical support, critically reading our manuscript, and their suggestions to improve the manuscript. We would also like to thank Ms. Tracy Winkle for her administrative support. This work was supported in part by grants from the National Institutes of Health ( R01-CA134777 , R01-HL140961 , R01-HL146137 , and R01-CA173852 to R.K.) and by funds to R.K. from the Riley Children’s Foundation . Z.C. is supported by National Institutes of Health grant T32HL007910 . We thank our colleagues for technical support, critically reading our manuscript, and their suggestions to improve the manuscript. We would also like to thank Ms. Tracy Winkle for her administrative support. This work was supported in part by grants from the National Institutes of Health (R01-CA134777, R01-HL140961, R01-HL146137, and R01-CA173852 to R.K.) and by funds to R.K. from the Riley Children's Foundation. Z.C. is supported by National Institutes of Health grant T32HL007910. Z.C. and R.K. conceived and designed the experiments, analyzed data, and wrote the manuscript. Z.C. performed most of the experiments and acquired the data. F.A. and B.R. assisted with certain experiments and acquired part of the data. S.V.D. S.C.J. and C.Z. did the bioinformatics analysis. J.J.K. M.C. G.W. A.W. and J.H.-M. contributed reagents and did the qRT-PCR for MORRBID and genotyping of FLT3ITD in human AML patients. The authors declare no competing interests.
Keywords
- BIM
- FLT3
- MORRBID
- TET2
- apoptosis
- leukemia
- lncRNA
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology