Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Zhigang Cai*, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J. Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao-Mejia, Reuben Kapur*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Cai et al. report that MORRBID/Morrbid expression is aberrantly increased in human AML patients and mouse models for CMML, MPN, and AML. Genetic loss of Morrbid makes leukemic cells vulnerable to apoptosis and mitigates the progression of myeloid neoplasms. High expression of MORRBID in humans is associated with poor survival of AML patients.

Original languageEnglish (US)
Article number107816
JournalCell reports
Volume31
Issue number12
DOIs
StatePublished - Jun 23 2020

Funding

We thank our colleagues for technical support, critically reading our manuscript, and their suggestions to improve the manuscript. We would also like to thank Ms. Tracy Winkle for her administrative support. This work was supported in part by grants from the National Institutes of Health ( R01-CA134777 , R01-HL140961 , R01-HL146137 , and R01-CA173852 to R.K.) and by funds to R.K. from the Riley Children’s Foundation . Z.C. is supported by National Institutes of Health grant T32HL007910 . We thank our colleagues for technical support, critically reading our manuscript, and their suggestions to improve the manuscript. We would also like to thank Ms. Tracy Winkle for her administrative support. This work was supported in part by grants from the National Institutes of Health (R01-CA134777, R01-HL140961, R01-HL146137, and R01-CA173852 to R.K.) and by funds to R.K. from the Riley Children's Foundation. Z.C. is supported by National Institutes of Health grant T32HL007910. Z.C. and R.K. conceived and designed the experiments, analyzed data, and wrote the manuscript. Z.C. performed most of the experiments and acquired the data. F.A. and B.R. assisted with certain experiments and acquired part of the data. S.V.D. S.C.J. and C.Z. did the bioinformatics analysis. J.J.K. M.C. G.W. A.W. and J.H.-M. contributed reagents and did the qRT-PCR for MORRBID and genotyping of FLT3ITD in human AML patients. The authors declare no competing interests.

Keywords

  • BIM
  • FLT3
  • MORRBID
  • TET2
  • apoptosis
  • leukemia
  • lncRNA

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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