Targeting Galectin-1 with self-assem bled multivalent pseudopolyrotaxanes

Jason M. Belitsky*, J. Fraser Stoddart

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This review describes the development of self-assembled multivalent pseudopolyrotaxanes as flexible and dynamic neoglycoconjugates for binding Galectin-1 (Gal-1). Gal-1, a dimeric lectin with two lactoside-binding sites, plays multiple roles in a variety of cancers. Pseudopolyrotaxanes comprised of lactoside-displaying cyclodextrin (LCD) "beads" threaded onto polyviologen "strings" display highly flexible and adaptable ligands as a result of rotation of the cyclodextrin torus about, and limited translation along, the polymer chain. The pseudopolyrotaxanes rapidly and efficiently precipitate GalI-1 and provide valency-corrected enhancements of up to 30-fold over native lactose and 20-fold over free LCD in a T-cell agglutination assay. These results show that the flexible and dynamic ligand presentation afforded by supramolecular assemblies, such as the pseudopolyrotaxanes, is a useful strategy for the study of protein-carbohydrate interactions and the exploitation of multivalency for targeting therapeutically relevant lectins.

Original languageEnglish (US)
Title of host publicationFrontiers in Modern Carbohydrate Chemistry
PublisherAmerican Chemical Society
Pages356-374
Number of pages19
ISBN (Print)0841239703, 9780841239708
DOIs
StatePublished - Jan 1 2007

Publication series

NameACS Symposium Series
Volume960
ISSN (Print)0097-6156

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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    Belitsky, J. M., & Stoddart, J. F. (2007). Targeting Galectin-1 with self-assem bled multivalent pseudopolyrotaxanes. In Frontiers in Modern Carbohydrate Chemistry (pp. 356-374). (ACS Symposium Series; Vol. 960). American Chemical Society. https://doi.org/10.1021/bk-2007-0960.ch019