Targeting Galectin-1 with self-assem bled multivalent pseudopolyrotaxanes

Jason M. Belitsky*, J. Fraser Stoddart

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


This review describes the development of self-assembled multivalent pseudopolyrotaxanes as flexible and dynamic neoglycoconjugates for binding Galectin-1 (Gal-1). Gal-1, a dimeric lectin with two lactoside-binding sites, plays multiple roles in a variety of cancers. Pseudopolyrotaxanes comprised of lactoside-displaying cyclodextrin (LCD) "beads" threaded onto polyviologen "strings" display highly flexible and adaptable ligands as a result of rotation of the cyclodextrin torus about, and limited translation along, the polymer chain. The pseudopolyrotaxanes rapidly and efficiently precipitate GalI-1 and provide valency-corrected enhancements of up to 30-fold over native lactose and 20-fold over free LCD in a T-cell agglutination assay. These results show that the flexible and dynamic ligand presentation afforded by supramolecular assemblies, such as the pseudopolyrotaxanes, is a useful strategy for the study of protein-carbohydrate interactions and the exploitation of multivalency for targeting therapeutically relevant lectins.

Original languageEnglish (US)
Title of host publicationFrontiers in Modern Carbohydrate Chemistry
PublisherAmerican Chemical Society
Number of pages19
ISBN (Print)0841239703, 9780841239708
StatePublished - 2007

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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