Targeting glucose metabolism for cancer therapy

Robert B. Hamanaka, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

234 Scopus citations

Abstract

Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic changes exhibited by tumor cells is an increase in glucose metabolism and glucose dependence. It has been hypothesized that targeting glucose metabolism may provide a selective mechanism by which to kill cancer cells. In this minireview, we discuss the benefits that high levels of glycolysis provide for tumor cells, as well as several key enzymes required by cancer cells to maintain this high level of glucose metabolism. It is anticipated that understanding which metabolic enzymes are particularly critical for tumor cell proliferation and survival will identify novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalJournal of Experimental Medicine
Volume209
Issue number2
DOIs
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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