Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models

Saktimayee M. Roy, Valerie L. Grum-Tokars, James P. Schavocky, Faisal Saeed, Agnieszka Staniszewski, Andrew F. Teich, Ottavio Arancio, Adam D. Bachstetter, Scott J. Webster, Linda J. Van Eldik, George Minasov, Wayne F. Anderson, Jeffrey C. Pelletier, D. Martin Watterson^*

^*Corresponding author for this work

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Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate
Roy, S. M. (Contributor), Grum-Tokars, V. L. (Contributor), Schavocky, J. P. (Contributor), Saeed, F. (Contributor), Staniszewski, A. (Contributor), Teich, A. F. (Contributor), Arancio, O. (Contributor), Bachstetter, A. D. (Contributor), Webster, S. J. (Contributor), Van Eldik, L. J. (Contributor), Minasov, G. (Contributor), Anderson, W. F. (Contributor), Pelletier, J. C. (Contributor) & Watterson, D. M. (Contributor), Protein Data Bank (PDB), Feb 25 2015
DOI: 10.2210/pdb4R3C/pdb, https://www.wwpdb.org/pdb?id=pdb_00004r3c
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Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer's Disease Mouse Models

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Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate