Targeting mitochondria metabolism for cancer therapy

Samuel E. Weinberg; Navdeep S. Chandel

doi:10.1038/nchembio.1712

Targeting mitochondria metabolism for cancer therapy

Samuel E. Weinberg, Navdeep S. Chandel

Research output: Contribution to journal › Review article › peer-review

1077 Scopus citations

Abstract

Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer.

Original language	English (US)
Pages (from-to)	9-15
Number of pages	7
Journal	Nature Chemical Biology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/nchembio.1712
State	Published - Jan 1 2015

Funding

This work is supported US National Institutes of Health grants R01CA123067 to N.S.C. and 5T32HL076139-10 to S.E.W. We apologize to all investigators whose work could not be cited due to reference limitations.

ASJC Scopus subject areas

Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nchembio.1712

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Targeting mitochondria metabolism for cancer therapy

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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