Targeting mitochondria metabolism for cancer therapy

Samuel E. Weinberg, Navdeep S. Chandel

Research output: Contribution to journalReview articlepeer-review

614 Scopus citations

Abstract

Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalNature Chemical Biology
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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