Targeting mitochondrial DNA with a platinum-based anticancer agent

Simon P. Wisnovsky, Justin J. Wilson, Robert J. Radford, Mark P. Pereira, Maria R. Chan, Rebecca R. Laposa, Stephen J. Lippard*, Shana O. Kelley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.

Original languageEnglish (US)
Pages (from-to)1323-1328
Number of pages6
JournalChemistry and Biology
Issue number11
StatePublished - Nov 21 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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