Targeting selective activation of M1 for the treatment of Alzheimers disease: Further chemical optimization and pharmacological characterization of the M1 positive allosteric modulator ML169

James C. Tarr*, Mark L. Turlington, Paul R. Reid, Thomas J. Utley, Douglas J. Sheffler, Hyekyung P. Cho, Rebecca Klar, Tristano Pancani, Michael T. Klein, Thomas M. Bridges, Ryan D. Morrison, Anna L. Blobaum, Zixui Xiang, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Michael R. Wood, Craig W. Lindsley

*Corresponding author for this work

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Medicine and Dentistry

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Pharmacology, Toxicology and Pharmaceutical Science