Abstract
Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin's inhibition of the PI3K/Akt/mTOR signaling pathways.
Original language | English (US) |
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Pages (from-to) | 971-978 |
Number of pages | 8 |
Journal | Anti-cancer agents in medicinal chemistry |
Volume | 13 |
Issue number | 7 |
DOIs | |
State | Published - 2013 |
Keywords
- Akt
- Apigenin
- Cancer
- MTOR
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research
- Pharmacology