Targeting the PI3k/Akt/mTOR axis by apigenin for cancer prevention

Xin Tong*, Jill C. Pelling

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Natural products are important sources of anti-cancer lead molecules, and high dietary consumption of fruits and vegetables is associated with a reduced risk of certain cancers. Many efforts have been devoted to identifying and developing plant-derived dietary constituents as chemopreventive agents. Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess remarkable anti-oxidant, anti-inflammatory and anti-carcinogenic properties. This review summarizes the anti-cancer and chemopreventive effects of apigenin at cellular and molecular levels, its chemical structure and properties, with focus on mechanism related to apigenin's inhibition of the PI3K/Akt/mTOR signaling pathways.

Original languageEnglish (US)
Pages (from-to)971-978
Number of pages8
JournalAnti-cancer agents in medicinal chemistry
Issue number7
StatePublished - 2013


  • Akt
  • Apigenin
  • Cancer
  • MTOR

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research
  • Pharmacology


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