Targeting the "species gene ensemble"

Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the 'genetic background' leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout which buffers the drastic compensatory reactions of the homozygous knockout thereby revealing subtle but yet consistent alterations in hippocampally-dependent behaviors.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
Issue number1
StatePublished - 2002


  • Gene targeting
  • Genetic background
  • Heterozygous knockouts
  • Knockout mice

ASJC Scopus subject areas

  • Cognitive Neuroscience


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