Targeting the stroma by T cells to limit tumor growth

Bin Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Solid tumors may modulate their environment and keep stromal cells in an immunosuppressive and tumor-promoting state. Recent findings indicate that targeting not only cancer cells but also nonmalignant stromal cells by T cells is required for the eradication of established tumor. Interestingly, a single adoptive transfer of effector T cells that recognize tumor antigen-loaded stromal cells, but not the cancer cells themselves, causes long-term inhibition of tumor growth associated with T cell-mediated killing of stromal CD11b +/Gr1+ myeloid cells. Therefore, targeting tumor stroma by T cells points to an important alternative approach to the effective control of tumor growth, particularly in the absence of direct targeting of cancer cells.

Original languageEnglish (US)
Pages (from-to)9570-9573
Number of pages4
JournalCancer Research
Volume68
Issue number23
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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