tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish

Dae Gwon Ahn, Ilya Ruvinsky, Andrew C. Oates, Lee M. Silver, Robert K. Ho

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

The T-box genes constitute a family of transcriptional regulator genes that have been implicated in a variety of developmental processes ranging from the formation of germ layers to the regionalization of the central nervous system. In this report we describe the cloning and expression pattern of a new T-box gene from zebrafish, which we named tbx20. tbx20 is an ortholog of two other T-box genes isolated from animals of different phyla - H15 of Drosophila melanogaster and tbx-12 of Caenorhabditis elegans, suggesting that the evolutionary origin of this gene predates the divergence between the protostomes and deuterostomes. During development, tbx20 is expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons, and the roof of the dorsal aorta. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalMechanisms of Development
Volume95
Issue number1-2
DOIs
StatePublished - Jul 1 2000

Keywords

  • Cranial motor neurons
  • Dorsal aorta
  • H15
  • Heart
  • Lateral plate mesoderm
  • T-box genes
  • TBX20
  • Zebrafish
  • cloche
  • tbx-12

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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