Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression

Chung S. Yang*, Guang Yu Yang, Janelle M. Landau, Sungbin Kim, Jie Liao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Both green and black tea have been shown to inhibit lung tumorigenesis in laboratory animal experiments. Green tea inhibited N-nitrosodiethylamine- induced lung tumor incidence and multiplicity in female A/J mice when tea was given either during the carcinogen treatment period or during the post- carcinogen treatment period. In a separate tumorigenesis model, both decaffeinated black tea and decaffeinated green tea inhibited 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumor formation. Studies in which tea was administered during different time periods in relation to the NNK suggest that tea can inhibit lung tumorigenesis at both the initiation and promotion stages. The antiproliferative effects of tea may be responsible for these anti- carcinogenic actions. Black tea polyphenol preparations decreased NNK- induced hyperproliferation. Black tea also inhibited the progression of pulmonary adenomas to adenocarcinomas and the formation of spontaneous lung tumors in A/J mice. Growth inhibition by various tea polyphenols has been demonstrated in human lung H661 and H1299 cells. Although inhibition of ceil growth and signal transduction pathways by tea components have been demonstrated, the concentrations required to produce the effect are higher than achievable in tissues in vivo. More research is necessary to translate these laboratory results to applications in human chemoprevention.

Original languageEnglish (US)
Pages (from-to)629-639
Number of pages11
JournalExperimental Lung Research
Issue number4
StatePublished - Jan 1 1998


  • Cell proliferation
  • Lung
  • Rhabdomyosarcoma
  • Tea
  • Tea polyphenols
  • Tumor genesis

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry

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