TEAD mediates YAP-dependent gene induction and growth control

Bin Zhao; Xin Ye; Jindan Yu; Li Li; Weiquan Li; Siming Li; Jianjun Yu; Jiandie D. Lin; Cun Yu Wang; Arul M. Chinnaiyan; Zhi Chun Lai; Kun Liang Guan

doi:10.1101/gad.1664408

TEAD mediates YAP-dependent gene induction and growth control

Bin Zhao, Xin Ye, Jindan Yu, Li Li, Weiquan Li, Siming Li, Jianjun Yu, Jiandie D. Lin, Cun Yu Wang, Arul M. Chinnaiyan, Zhi Chun Lai, Kun Liang Guan^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

1654 Scopus citations

Abstract

The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

Original language	English (US)
Pages (from-to)	1962-1971
Number of pages	10
Journal	Genes and Development
Volume	22
Issue number	14
DOIs	https://doi.org/10.1101/gad.1664408
State	Published - Jul 15 2008

Keywords

CTGF
Cancer
Hippo
TEAD
Transcription
YAP

ASJC Scopus subject areas

Genetics
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1101/gad.1664408

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title = "TEAD mediates YAP-dependent gene induction and growth control",

abstract = "The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.",

keywords = "CTGF, Cancer, Hippo, TEAD, Transcription, YAP",

author = "Bin Zhao and Xin Ye and Jindan Yu and Li Li and Weiquan Li and Siming Li and Jianjun Yu and Lin, {Jiandie D.} and Wang, {Cun Yu} and Chinnaiyan, {Arul M.} and Lai, {Zhi Chun} and Guan, {Kun Liang}",

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T1 - TEAD mediates YAP-dependent gene induction and growth control

AU - Zhao, Bin

AU - Ye, Xin

AU - Yu, Jindan

AU - Li, Li

AU - Li, Weiquan

AU - Li, Siming

AU - Yu, Jianjun

AU - Lin, Jiandie D.

AU - Wang, Cun Yu

AU - Chinnaiyan, Arul M.

AU - Lai, Zhi Chun

AU - Guan, Kun Liang

PY - 2008/7/15

Y1 - 2008/7/15

N2 - The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

AB - The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.

KW - CTGF

KW - Cancer

KW - Hippo

KW - TEAD

KW - Transcription

KW - YAP

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DO - 10.1101/gad.1664408

M3 - Article

C2 - 18579750

AN - SCOPUS:47549095853

SN - 0890-9369

VL - 22

SP - 1962

EP - 1971

JO - Genes and Development

JF - Genes and Development

IS - 14

ER -

TEAD mediates YAP-dependent gene induction and growth control

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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