Technetium-99M sulfur colloid scanning and correlative magnetic resonance imaging in patients with hairy cell leukemia and hypocellular bone marrow biopsies after 2-chlorodeoxyadenosine

Richard S. Siegel, David Hakimian, William Spies, Eric R. Wollins, Loann C. Peterson, Joel Meyer, Martin S. Tallman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

It has been observed that some patients in complete remission (CR) after 2-chlorodeoxyadenosine (2-CdA) for hairy cell leukemia (HCL) have hypocellular bone marrow biopsies despite normal peripheral blood cell counts. This discrepancy between bone marrow cellularity and peripheral blood cell counts suggests the possibility of abnormal sites of hematopoiesis. To determine sites of hematopoieses, 11 radionuclide (99mTc) sulfur colloid were performed in eight patients. Although no single, pattern was observed on the 99mTc sulfur colloid scans, two of the eight patients, both with virtually aplastic marrows, had multiple areas of increased uptake in the distal appendicular skeleton, suggesting abnormal sites of hematopoiesis. The same two patients had magnetic resonance imaging (MRI), which confirmed the abnormal sites of hematopoiesis.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalLeukemia and Lymphoma
Volume35
Issue number1-2
DOIs
StatePublished - 1999

Keywords

  • 2-Chlorodeoxyadenosine
  • Hairy cell leukemia
  • Hematopoiesis
  • Magnetic resonance imaging
  • Sulfur colloid scanning

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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