Technical Aspects of Radioembolization with 90Y Microspheres

Riad Salem*, Robert J. Lewandowski, Kent T. Sato, Bassel Atassi, Robert K. Ryu, Saad Ibrahim, Albert A. Nemcek, Reed A. Omary, David C. Madoff, Ravi Murthy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Embolotherapy with radioactive microspheres, radioembolization, is gaining clinical acceptance as a therapeutic option for patients with liver malignancies. Knowledge of the anatomic variants in the mesenteric system is critical to safely administer this therapy. The purpose of this review is to provide a thorough discussion and detailed presentation of the technical aspects of radioembolization specifically as it pertains to the implantation devices. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. In addition, the basic principles described in this manuscript apply to all liver-directed transarterial therapies, such as chemoembolization and/or drug-eluting microspheres.

Original languageEnglish (US)
Pages (from-to)12-29
Number of pages18
JournalTechniques in Vascular and Interventional Radiology
Issue number1
StatePublished - Mar 2007


  • SIR-Spheres
  • TheraSphere
  • Yttrium-90
  • brachytherapy
  • embolization
  • liver cancer
  • radioembolization
  • radiotherapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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