Techniques of assessing hypoxia at the bench and bedside

C. E. Evans*, K. Mattock, J. Humphries, P. Saha, A. Ahmad, M. Waltham, A. Patel, B. Modarai, L. Porter, S. Premaratne, A. Smith

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Tissues require an adequate supply of oxygen in order to maintain normal cell function. Low oxygen tension (hypoxia) is characteristic of a number of conditions, including cancer, atherosclerosis, rheumatoid arthritis, critical limb ischaemia, peripheral vascular disease, and ischaemic heart disease. Tissue hypoxia is found in tumours, atherosclerotic plaque, and ischaemic myocardium. There is a growing interest in methods to detect and assess hypoxia, given that hypoxia is important in the progression of these diseases. Hypoxia can be assessed at the level of the whole organ, tissue, or cell, using both invasive and non-invasive methods, and by a range of immunohistochemical, biochemical, or imaging techniques. This review describes and critiques current methods of assessing hypoxia that are used at the bench and in clinical practice.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalAngiogenesis
Volume14
Issue number2
DOIs
StatePublished - May 2011

Keywords

  • Hypoxia
  • Ischaemia
  • Methods
  • Oxygen
  • Oxygenation

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cancer Research

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