Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice

Roozbeh Ghaffari*, Shirin Farrahi, Alexander J. Aranyosi, Guy P. Richardson, Dennis M. Freeman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We show that the Tectb mutation reduces the spatial extent and propagation velocity of tectorial membrane (TM) traveling waves. These results can account for all of the hearing abnormalities associated with the Tectb mutation, as follows. By reducing the spatial extent of TM waves, the Tectb mutation decreases spread of excitation and thereby increases frequency selectivity at mid- to high frequencies. Furthermore, the decrease in Tectb TM wave velocity at low frequencies reduces the number of hair cells that effectively couple energy to the basilar membrane, which thereby reduces sensitivity.

Original languageEnglish (US)
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages85-89
Number of pages5
Volume1403
DOIs
StatePublished - Dec 12 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

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Keywords

  • cochlear amplification
  • frequency selectivity
  • spread of excitation
  • tectb
  • tectorial membrane
  • traveling waves

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Ghaffari, R., Farrahi, S., Aranyosi, A. J., Richardson, G. P., & Freeman, D. M. (2011). Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (Vol. 1403, pp. 85-89) https://doi.org/10.1063/1.3658065