Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice

Roozbeh Ghaffari; Shirin Farrahi; Alexander J. Aranyosi; Guy P. Richardson; Dennis M. Freeman

doi:10.1063/1.3658065

Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice

Roozbeh Ghaffari^*, Shirin Farrahi, Alexander J. Aranyosi, Guy P. Richardson, Dennis M. Freeman

^*Corresponding author for this work

QSIB - Querrey Simpson Institute for Bioelectronics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We show that the Tectb mutation reduces the spatial extent and propagation velocity of tectorial membrane (TM) traveling waves. These results can account for all of the hearing abnormalities associated with the Tectb mutation, as follows. By reducing the spatial extent of TM waves, the Tectb mutation decreases spread of excitation and thereby increases frequency selectivity at mid- to high frequencies. Furthermore, the decrease in Tectb TM wave velocity at low frequencies reduces the number of hair cells that effectively couple energy to the basilar membrane, which thereby reduces sensitivity.

Original language	English (US)
Title of host publication	What Fire is in Mine Ears
Subtitle of host publication	Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages	85-89
Number of pages	5
Volume	1403
DOIs	https://doi.org/10.1063/1.3658065
State	Published - Dec 12 2011
Event	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States Duration: Jul 16 2011 → Jul 22 2011

Other

Other	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
Country/Territory	United States
City	Williamstown, MA
Period	7/16/11 → 7/22/11

Keywords

cochlear amplification
frequency selectivity
spread of excitation
tectb
tectorial membrane
traveling waves

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/1.3658065

Cite this

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title = "Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice",

abstract = "We show that the Tectb mutation reduces the spatial extent and propagation velocity of tectorial membrane (TM) traveling waves. These results can account for all of the hearing abnormalities associated with the Tectb mutation, as follows. By reducing the spatial extent of TM waves, the Tectb mutation decreases spread of excitation and thereby increases frequency selectivity at mid- to high frequencies. Furthermore, the decrease in Tectb TM wave velocity at low frequencies reduces the number of hair cells that effectively couple energy to the basilar membrane, which thereby reduces sensitivity.",

keywords = "cochlear amplification, frequency selectivity, spread of excitation, tectb, tectorial membrane, traveling waves",

author = "Roozbeh Ghaffari and Shirin Farrahi and Aranyosi, {Alexander J.} and Richardson, {Guy P.} and Freeman, {Dennis M.}",

year = "2011",

month = dec,

day = "12",

doi = "10.1063/1.3658065",

language = "English (US)",

isbn = "9780735409750",

volume = "1403",

pages = "85--89",

booktitle = "What Fire is in Mine Ears",

note = "11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics ; Conference date: 16-07-2011 Through 22-07-2011",

}

Ghaffari, R, Farrahi, S, Aranyosi, AJ, Richardson, GP & Freeman, DM 2011, Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice. in What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. vol. 1403, pp. 85-89, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 7/16/11. https://doi.org/10.1063/1.3658065

Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice. / Ghaffari, Roozbeh; Farrahi, Shirin; Aranyosi, Alexander J. et al.
What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403 2011. p. 85-89.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice

AU - Ghaffari, Roozbeh

AU - Farrahi, Shirin

AU - Aranyosi, Alexander J.

AU - Richardson, Guy P.

AU - Freeman, Dennis M.

PY - 2011/12/12

Y1 - 2011/12/12

N2 - We show that the Tectb mutation reduces the spatial extent and propagation velocity of tectorial membrane (TM) traveling waves. These results can account for all of the hearing abnormalities associated with the Tectb mutation, as follows. By reducing the spatial extent of TM waves, the Tectb mutation decreases spread of excitation and thereby increases frequency selectivity at mid- to high frequencies. Furthermore, the decrease in Tectb TM wave velocity at low frequencies reduces the number of hair cells that effectively couple energy to the basilar membrane, which thereby reduces sensitivity.

AB - We show that the Tectb mutation reduces the spatial extent and propagation velocity of tectorial membrane (TM) traveling waves. These results can account for all of the hearing abnormalities associated with the Tectb mutation, as follows. By reducing the spatial extent of TM waves, the Tectb mutation decreases spread of excitation and thereby increases frequency selectivity at mid- to high frequencies. Furthermore, the decrease in Tectb TM wave velocity at low frequencies reduces the number of hair cells that effectively couple energy to the basilar membrane, which thereby reduces sensitivity.

KW - cochlear amplification

KW - frequency selectivity

KW - spread of excitation

KW - tectb

KW - tectorial membrane

KW - traveling waves

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SP - 85

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BT - What Fire is in Mine Ears

T2 - 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics

Y2 - 16 July 2011 through 22 July 2011

ER -

Tectorial membrane traveling waves underlie impaired hearing in Tectb mutant mice

Abstract

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Keywords

ASJC Scopus subject areas

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