Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia

Srdan Verstovsek; Francis J. Giles; Susan O'Brien; Stefan Faderl; Hagop M. Kantarjian; Michael J. Keating; Maher Albitar

doi:10.1016/j.leukres.2003.11.009

Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia

Srdan Verstovsek, Francis J. Giles, Susan O'Brien, Stefan Faderl, Hagop M. Kantarjian, Michael J. Keating, Maher Albitar^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We measured telomerase activity (TA) in bone marrow samples from 214 patients with CLL and correlated it with patients' characteristics and survival. In >50% of cases (126/214; 59%) no detectable TA was found. There was no difference in TA between previously treated (n=153) and untreated (n=61) patients (P=0.4), or patients with various Rai (0-IV) stages (P=0.85). TA correlated significantly with white blood cell and lymphocyte count (P=0.02 and 0.01, respectively) but not with bone marrow cellularity, β2-microglobulin (β2M), or other patient characteristics. Patients who had no TA had slightly lower β2M and lower lymphocyte counts (P=0.5 and 0.04, respectively) as compared with patients with detectable TA. However, there was no correlation between TA and survival. This data suggests that TA may not play a significant role in the clinical behavior of CLL.

Original language	English (US)
Pages (from-to)	707-711
Number of pages	5
Journal	Leukemia Research
Volume	28
Issue number	7
DOIs	https://doi.org/10.1016/j.leukres.2003.11.009
State	Published - Jul 2004

Keywords

CLL
Chronic lymphocytic leukemia
PCR
Prognosis
Survival
TA
TRAP
Telomerase activity
chronic lymphocytic leukemia
polymerase chain reaction
telomerase activity
telomeric repeat amplification protocol

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2003.11.009

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title = "Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia",

abstract = "We measured telomerase activity (TA) in bone marrow samples from 214 patients with CLL and correlated it with patients' characteristics and survival. In >50% of cases (126/214; 59%) no detectable TA was found. There was no difference in TA between previously treated (n=153) and untreated (n=61) patients (P=0.4), or patients with various Rai (0-IV) stages (P=0.85). TA correlated significantly with white blood cell and lymphocyte count (P=0.02 and 0.01, respectively) but not with bone marrow cellularity, β2-microglobulin (β2M), or other patient characteristics. Patients who had no TA had slightly lower β2M and lower lymphocyte counts (P=0.5 and 0.04, respectively) as compared with patients with detectable TA. However, there was no correlation between TA and survival. This data suggests that TA may not play a significant role in the clinical behavior of CLL.",

keywords = "CLL, Chronic lymphocytic leukemia, PCR, Prognosis, Survival, TA, TRAP, Telomerase activity, chronic lymphocytic leukemia, polymerase chain reaction, telomerase activity, telomeric repeat amplification protocol",

author = "Srdan Verstovsek and Giles, {Francis J.} and Susan O'Brien and Stefan Faderl and Kantarjian, {Hagop M.} and Keating, {Michael J.} and Maher Albitar",

year = "2004",

month = jul,

doi = "10.1016/j.leukres.2003.11.009",

language = "English (US)",

volume = "28",

pages = "707--711",

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AU - Verstovsek, Srdan

AU - Giles, Francis J.

AU - O'Brien, Susan

AU - Faderl, Stefan

AU - Kantarjian, Hagop M.

AU - Keating, Michael J.

AU - Albitar, Maher

PY - 2004/7

Y1 - 2004/7

N2 - We measured telomerase activity (TA) in bone marrow samples from 214 patients with CLL and correlated it with patients' characteristics and survival. In >50% of cases (126/214; 59%) no detectable TA was found. There was no difference in TA between previously treated (n=153) and untreated (n=61) patients (P=0.4), or patients with various Rai (0-IV) stages (P=0.85). TA correlated significantly with white blood cell and lymphocyte count (P=0.02 and 0.01, respectively) but not with bone marrow cellularity, β2-microglobulin (β2M), or other patient characteristics. Patients who had no TA had slightly lower β2M and lower lymphocyte counts (P=0.5 and 0.04, respectively) as compared with patients with detectable TA. However, there was no correlation between TA and survival. This data suggests that TA may not play a significant role in the clinical behavior of CLL.

AB - We measured telomerase activity (TA) in bone marrow samples from 214 patients with CLL and correlated it with patients' characteristics and survival. In >50% of cases (126/214; 59%) no detectable TA was found. There was no difference in TA between previously treated (n=153) and untreated (n=61) patients (P=0.4), or patients with various Rai (0-IV) stages (P=0.85). TA correlated significantly with white blood cell and lymphocyte count (P=0.02 and 0.01, respectively) but not with bone marrow cellularity, β2-microglobulin (β2M), or other patient characteristics. Patients who had no TA had slightly lower β2M and lower lymphocyte counts (P=0.5 and 0.04, respectively) as compared with patients with detectable TA. However, there was no correlation between TA and survival. This data suggests that TA may not play a significant role in the clinical behavior of CLL.

KW - CLL

KW - Chronic lymphocytic leukemia

KW - PCR

KW - Prognosis

KW - Survival

KW - TA

KW - TRAP

KW - Telomerase activity

KW - chronic lymphocytic leukemia

KW - polymerase chain reaction

KW - telomerase activity

KW - telomeric repeat amplification protocol

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SN - 0145-2126

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JO - Leukemia Research

JF - Leukemia Research

IS - 7

ER -

Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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