Temperature-activated nucleic acid nanostructures

Ke Zhang; Xiao Zhu; Fei Jia; Evelyn Auyeung; Chad A. Mirkin

doi:10.1021/ja408465t

Temperature-activated nucleic acid nanostructures

Ke Zhang^*, Xiao Zhu, Fei Jia, Evelyn Auyeung, Chad A. Mirkin

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.

Original language	English (US)
Pages (from-to)	14102-14105
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	38
DOIs	https://doi.org/10.1021/ja408465t
State	Published - Sep 25 2013

ASJC Scopus subject areas

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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10.1021/ja408465t

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abstract = "DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.",

author = "Ke Zhang and Xiao Zhu and Fei Jia and Evelyn Auyeung and Mirkin, {Chad A.}",

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AU - Zhang, Ke

AU - Zhu, Xiao

AU - Jia, Fei

AU - Auyeung, Evelyn

AU - Mirkin, Chad A.

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Y1 - 2013/9/25

N2 - DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.

AB - DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.

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Temperature-activated nucleic acid nanostructures

Abstract

ASJC Scopus subject areas

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