Temperature-activated nucleic acid nanostructures

Ke Zhang*, Xiao Zhu, Fei Jia, Evelyn Auyeung, Chad A. Mirkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.

Original languageEnglish (US)
Pages (from-to)14102-14105
Number of pages4
JournalJournal of the American Chemical Society
Issue number38
StatePublished - Sep 25 2013

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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