Temperature controlled grafted polymer network incorporated with magnetic nano particles to control drug release induced by an external magnetothermal trigger

Induvadana Ankareddi, Mary L. Hampel, Mary Kathryn Sewell, Dong Hyun Kim, Christopher S. Brazel*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event was developed. The desirable carrier will have minimal release at 37°C so that the system can be localized (e.g., to cancer cells) prior to activation of the delivery of medication. The grafted hydrogel system is shown to exhibit a desirable positive thermal response with an increased drug diffusion coefficient for temperatures higher than physiological temperature.

Original languageEnglish (US)
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages431-434
Number of pages4
Volume2
StatePublished - Aug 23 2007
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: May 20 2007May 24 2007

Other

Other2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
CountryUnited States
CitySanta Clara, CA
Period5/20/075/24/07

Keywords

  • Grafted
  • Hydrogel
  • Thermosensitive

ASJC Scopus subject areas

  • Mechanical Engineering

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    Ankareddi, I., Hampel, M. L., Sewell, M. K., Kim, D. H., & Brazel, C. S. (2007). Temperature controlled grafted polymer network incorporated with magnetic nano particles to control drug release induced by an external magnetothermal trigger. In 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings (Vol. 2, pp. 431-434)