Templated spherical high density lipoprotein nanoparticles

C. Shad Thaxton, Weston L. Daniel, David A. Giljohann, Audrey D. Thomas, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

We report the synthesis of high density lipoprotein (HDL) biomimetic nanoparticles capable of binding cholesterol. These structures use a gold nanoparticle core to template the assembly of a mixed phospholipid layer and the adsorption of apolipoprotein A-I. These synthesized structures have the general size and surface composition of natural HDL and, importantly, bind free cholesterol (K d = 4 nM). The determination of the K d for these particles, with respect to cholesterol complexation, provides a key starting and comparison point for measuring and evaluating the properties of subsequently developed synthetic versions of HDL.

Original languageEnglish (US)
Pages (from-to)1384-1385
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number4
DOIs
StatePublished - Feb 4 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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