Templated synthesis of interlocked molecules

Fabio Aricó, Jovica D. Badjic, Stuart J. Cantrill, Amar H. Flood, Ken C F Leung, Yi Liu, J. Fraser Stoddart*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

163 Scopus citations

Abstract

Mechanically interlocked molecular compounds can be synthesized in high yields by using template-directed assistance to covalent synthesis. Catenanes and rotaxanes are two classes of mechanically interlocked molecules that have been prepared using a variety of methods such as "clipping", "slipping", and "threading-followed-by-stoppering", under both kinetic and thermodynamic regimes. These different methods have utilized a range of templates such as transistion metals, π-donor/π-acceptors, and hydrogen-bonding motifs. Multivalency has emerged as another tool to aid and abet the supramolecularly assisted synthesis of mechanically interlocked molecules. Recent advances in our understanding of the nature of the mechanical bond has led to the construction of molecular machines with controllable motions that have, in one instance, been introduced into molecular electronic devices.

Original languageEnglish (US)
Title of host publicationTemplates in Chemistry II
EditorsChristoph Schalley, Karl Doetz, Fritz Voegtle
Pages203-259
Number of pages57
DOIs
StatePublished - Jun 15 2005

Publication series

NameTopics in Current Chemistry
Volume249
ISSN (Print)0340-1022

Keywords

  • Catenanes
  • Dynamic chemistry
  • Molecular machines
  • Multivalency
  • Rotaxanes

ASJC Scopus subject areas

  • Chemistry(all)

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