Temporal trends in human immunodeficiency virus type 1 seroconversion 1984-1989: A report from the multicenter AIDS cohort study (macs)

Lawrence A. Kingsley*, Susan Y.J. Zhou, Helena Bacellar, Charles R. Rinaldo, Joan S Chmiel, Roger Detels, Alfred Saah, Mark Vanraden, Monto Ho, Alvaro Muñoz

*Corresponding author for this work

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

The 5-year temporal trends in human immunodeficiency virus type 1 (HIV-1) seroconversion between 1984 and 1989 among homosexual/bisexual men participating in the Multicenter AIDS Cohort Study (MACS) are reported. Of 3,262 initially seronegative men, 368 (11.3%) had seroconverted by December 31, 1989. Although the incidence of seroconversion declined precipitously during the first 3 years of follow-up (from 4.1% to 0.9% per 6 months), no evidence for a further substantial reduction was noted after mid-1987, since 6-month incidence rates ranged between 0.5% and 1.2%. The Chicago cohort experienced an increase in HIV-1 seroconversion during both semesters of 1989; 2.1% and 1.6% per 6 months, respectively, became newly infected. Other MACS centers did not report such an increase. Center-specific differences were observed by race; black men were at higher seroconversion risk than white men in Baltimore/Washington (relative risk (RR) = 3.4) and Chicago (RR = 2.4), while Hispanic men were at higher risk than white men in Chicago (RR = 3.3). Younger age (<35 years) was also associated with HIV-1 seroconversion (RR = 1.5). It is disturbing to report an overall annual seroconversion rate of 1.2% for the 2 years prior to December 31, 1989, as well as evidence for a sustained recent increase in Chicago during 1989. Long-term maintenance of safe-sex behaviors should be the cornerstone of acquired immunodeficiency syndrome prevention among homosexual/bisexual men.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalAmerican Journal of Epidemiology
Volume134
Issue number4
DOIs
StatePublished - Aug 15 1991

Keywords

  • Acquired immunodeficiency syndrome
  • HIV
  • HIV seropositivity
  • HIV seroprevalence

ASJC Scopus subject areas

  • Epidemiology

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